Real Nameįun Fact: On the day of Jordan Knight’s birth, "American Woman" by Guess Who was the number 1 song on The Billboard Hot 100 and Richard Nixon (Republican) was the U.S. Donnie Wahlberg recruited him because of his great falsetto voice. On May 31, 2011, he released the studio album, Unfinished. He had sold over 1.5 million records worldwide as a solo artist. He has released three studio albums, one remix album and one EP.
As of 2011, he released four Top 40 singles the most well known being “Give It to You” in 1999. Jordan’s first solo album, released in 1999, and his latest solo album, released in 2011, reached the Top 50 on the US Billboard 200. After New Kids on the Block split, he launched a solo career. He is best known for his distinctive falsetto style of singing, influenced by The Stylistics. These findings revealed a novel role for retinoic acid in the imprinting of gut-homing specificity on T cells.Jordan Nathaniel Marcel Knight is an American singer-songwriter best known as the lead singer in the boy band New Kids on the Block (NKOTB), and as an actor, who rose to fame in the 1980s and 1990s. Accordingly, vitamin A deficiency caused a reduction in α4β7 + memory/activated T cells in lymphoid organs and a depletion of T cells from the intestinal lamina propria. The enhanced α4β7 expression on T cells by antigenic stimulation with these dendritic cells was suppressed by the retinal dehydrogenase inhibitor citral and the retinoic acid receptor antagonist LE135. Dendritic cells from the gut-associated lymphoid organs produced retinoic acid from retinol. Here, we show that the vitamin A (retinol) metabolite, retinoic acid, enhances the expression of α4β7 and CCR9 on T cells upon activation and imprints them with the gut tropism.
For a preferential homing of T cells to the gut, expression of the integrin α4β7 and the chemokine receptor CCR9 is essential and is induced by antigenic stimulation with dendritic cells from the gut-associated lymphoid organs.
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